Epitope Recognition by Diverse Antibodies Suggests Conformational Convergence in an Antibody Response
نویسندگان
چکیده
منابع مشابه
Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response.
Crystal structures of distinct mAbs that recognize a common epitope of a peptide Ag have been determined and analyzed in the unbound and bound forms. These Abs display dissimilar binding site structures in the absence of the Ag. The dissimilarity is primarily expressed in the conformations of complementarity-determining region H3, which is responsible for defining the epitope specificity. Inter...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2002
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.168.5.2371